OrthoMune | Calabasas Medicine Group

Quercetin is best known for its antioxidant activity in scavenging free radicals. Additionally, quercetin helps balance cytokine levels and improve T-lymphocyte balance. Several mechanism studies highlight quercetin's ability to provide immune system support while also stimulating the ciliary beat frequency of the nasal epithelium, aiding the excretion of respiratory mucus. Quercetin has been shown to block the mechanisms by which microbes enter host cells and replicate within the body. Additionally, a human clinical trial found quercetin supplementation supported healthy respiratory function following a stressor (i.e., intense bout of exercise), compared to placebo.

Vitamin C is a potent antioxidant that has been studied for many years for its immune-supporting effects. Through its antioxidant functions, vitamin C has been shown to protect important immune cells from oxidative damage. Data shows vitamin C is heavily concentrated in macrophages, supports lymphocyte activity, modulates cytokine release, improves endothelial function, restores mitochondrial function, and can directly support a challenged immune system. Of particular interest, vitamin C has been shown to recycle oxidized quercetin back to its parent compound, which supports a robust immune response while increasing the efficacy of quercetin.

N-acetyl cysteine (NAC) is the precursor of the master antioxidant, glutathione. NAC has been shown to support mucus clearance and normal respiratory function through its ability to cleave disulfide bonds in mucus. NAC is found to raise glutathione levels, which is important to protect the biological activity and safe metabolism of quercetin. Along with protecting the activity of quercetin, NAC supports all detoxification pathways and helps maintain immune balance by supporting glutathione levels.

It has been shown that low vitamin D levels have immunologic implications with a significant decrease in immune function, affecting respiratory health. This is most likely because the vitamin D receptor is expressed by several immune cells, including monocytes, macrophages, dendritic cells, and B and T cells. Supplementation with vitamin D has been shown to modulate NK cell activity to promote a healthy innate immune response. Along with these immune-supporting benefits, vitamin D has also been shown to support the respiratory system and epithelial tight junction integrity.

Zinc is an essential trace mineral that plays a critical role in immune function. Zinc is required for the normal development and function of cells mediating innate immunity, including neutrophils and natural killer cells. Zinc deficiency has been shown to impair immune function, and supplementation has been shown to support immune cell activity, including T-cell function and antibody production. Zinc also plays a synergistic role with quercetin, supporting its transport into cells to promote a robust immune response.