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CLINICAL APPLICATIONS
• Maintains Normal Inflammatory Balance
• Supports Microbiome Diversity
• Potent Antioxidant Action
• Enhances and Balances Immune Function
IMMUNE HEALTH
Turiva® contains an exclusive blend of bioactive phytonutrients that make up the Complete Turmeric Matrix for increased clinical efficacy. It is a natural complex that includes curcumin, turmerones, turmerin, curcumol, cyclocurcumin, curdione and B-elemene making it a comprehensive, immune-boosting turmeric supplement.
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Overview
Modern lifestyle choices, such as an unbalanced diet and poor nutrition, have a major impact on health determinants. Immune and inflammatory challenges arise when our bodies cannot keep up with the demands of handling stress, toxin removal and cellular function preservation. Turiva® provides a well-rounded blend of turmeric phytonutrients that can help support normal inflammatory input and strengthen immune reserves.1 The formula targets various proinflammatory markers and supports healthy breathing, cognitive function, gut and immune function.1,2 The molecular structure of turmeric’s components–proteins, fibers, carbohydrates and volatile oilscontributes to its bioefficacy and maximizes its pleiotropic effects, making it an essential phytonutrient to combat various inflammatory pathways in our body.
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Turmeric (Complete Turmeric Matrix)
The body’s ability to produce and metabolize CoQ10 has been reported to decrease with age. CoQ10 deficiency may be caused by insufficient dietary intake of CoQ10, impairment in CoQ10 production, drug-induced CoQ10 depletion, gene mutations, and oxidative stress. HMG-CoA reductase is an enzyme required for the synthesis of cholesterol and CoQ10. Cholesterol lowering medications inhibit this enzyme in order to reduce cholesterol synthesis, but may also simultaneously deplete CoQ10 status.
Thirteen controlled studies conducted between 1990-2004 demonstrated significant CoQ10 depletion, secondary to use of statin medications used to lower cholesterol levels. These studies demonstrated a range of 19-54% decrease in CoQ10 levels in patients on statin therapy. In the event of CoQ10 depletion, supplementation can improve CoQ10 status and help maintain optimal levels in the body.
• Curcumin: Activates alkaline phosphatase that decreases LPS activity and inhibits the expression of the NF-kB/IkB pathway.
• Turmerones: Enhance the bioavailability and bioactivity of curcumin.
• Turmerin: Inhibits oxidative DNA damage, formation of lipid peroxides, and arachidonic acid release.
• Curcumol: Inhibits oxidative stress and targets key signaling pathways MAPK/ERK, PI3K/Akt and NF-kB.
• Cyclocurcumin: Exhibits synergistic bioactivity with curcumin and inhibits the release of TNF-alpha.
• Curdione: Inhibits the production of prostaglandin E2 (PGE2) and COX-2 expression.
• B-elemene: Downregulates pro-inflammatory cytokines TNFalpha, IFN, TGF-beta, IL-6 and IL-10.
This matrix of bioactive compounds supports a healthy GI tract, enhances detoxification, creates a healthy microbiome, and helps maintain normal inflammatory balance.
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Turmeric and Immune Health
Turmeric and its phytonutrients, like curcumin, have been shown to support lowering of lipid peroxidation by maintaining the activity of antioxidant enzymes, such as superoxide dismutase, catalase and glutathione peroxidase, at higher levels.1 In animal studies, curcumin was reported to decrease the release of reactive oxygen species from macrophages and inhibit histamine release from mast cells.2 The chemical structure of the curcumin molecule allows it to have a significant effect on oxidative stress and immune-mediated reactions.13 However, several findings indicate that antioxidant and protective effects are synergistically enhanced when other turmeric components are included.21 Other turmeric components, such as turmerones,5,21 curdione,10,22,23 curcumol,7 cyclocurcumin,8,9 turmerin6,24 and β-elemene,11,12,25 all have significant impact on immune health and maintaining normal inflammatory balance.
A complete turmeric matrix was tested for its impact on immune cells. The test results showed it had a three-fold increase in phagocytic ability.17 Due to its pleiotropic effects and ability to pursue multiple inflammatory targets, turmeric has proven uses as an immune-boosting agent. A meta-analysis of eight randomized, controlled trials indicated that doses of 1,000 mg of curcumin per day were effective in balancing overactive immune challenges.19 In a randomized, double-blind, placebo-controlled clinical trial published in the Journal of Medicinal Food, a total of 36 patients with immune challenges were included to test out the efficacy of a complete turmeric matrix. A dose of 250 mg or 500 mg of the turmeric product was given twice a day to the patients in the treatment groups. Specific objective measures and lab markers were used to assess the response of these patients. The results indicated that a complete turmeric formulation improved objective measurements and maintained normal inflammatory balance.18 (See Figure: 1)
Turmeric and Gut Health
All sources of orally consumed nutrients must pass through the gut before moving along to the rest of the body. Likewise, the gut microbiome is now considered influential in every aspect of human metabolism, making it an important mediator of phytonutrients. Therefore, the gut and its microbiota are the primary targets of medicinal compounds like turmeric. Turmeric and its phytonutrients, like curcumin, have been shown to support expression of protective proteins such as Nrf2. They also support normal balance of the expression of various inflammatory agents in the gut, such as NFkB, COX enzyme(s), and matrix metalloproteinase-9. In addition, they boost NK cell activity.1,14,15 The mechanism of action of curcumin is that it can indirectly bind to toll-like receptor 4 (TLR4).20 Literature indicates that this action supports a balance in the innate immune response to lipopolysaccharides (LPS).20 Furthermore, turmeric can help attenuate LPS-induced cytokine release and tight junction protein disruption. Other, non-curcuminoid compounds, such as curdione and germacrone, also help balance LPS-induced immune challenges.22 This promotes overall gut mucosal health and helps create equilibrium in inflammatory responses.
Turmeric Bioactivity vs. Bioefficacy
Bioavailability is defined as the delivery of a biologically active compound to a target tissue; it is not simply the absorption of higher amounts of the nutrient into the blood. There has been continuous debate on the bioavailability of curcumin, and it is important to note that most clinical research of turmeric-derived compounds is focused on curcuminoid activity.13 Curcuminoids undergo extensive metabolism during and after ingestion.13 This is one of the key reasons curcumin is encouraged to be consumed with an adjuvant or made with “bioavailability enhancers” that dilute the breakdown process. However, these enhanced versions show no significant impact in human clinical studies. Studies showing increased absorption have not demonstrated increased positive clinical outcomes. Based on this, it is important to shift focus to bioefficacy, or the effectiveness of a material in a biological environment, over bioavailability. Components of the whole turmeric root have proven that the therapeutic effect of turmeric extends beyond curcuminoids alone.
Directions
1 capsule per day or as recommended by your health care professional.
Does Not Contain
Gluten, corn, yeast, artificial colors or flavors.
Caution
Do not consume this product if you are pregnant or nursing.
The information was obtained from Ortho Molecular