Turiva® | Calabasas Medicine Group

Modern lifestyle choices, such as an unbalanced diet and poor nutrition, have a major impact on health determinants. Immune and inflammatory challenges arise when our bodies cannot keep up with the demands of handling stress, toxin removal and cellular function preservation. Turiva® provides a well-rounded blend of turmeric phytonutrients that can help support normal inflammatory input and strengthen immune reserves. The formula targets various proinflammatory markers and supports healthy breathing, cognitive function, gut and immune function. The molecular structure of turmeric's components — proteins, fibers, carbohydrates and volatile oils — contributes to its bioefficacy and maximizes its pleiotropic effects, making it an essential phytonutrient to combat various inflammatory pathways in our body.

Turiva® delivers a full spectrum of turmeric bioactives, each with distinct mechanisms of action that work synergistically. Curcumin activates alkaline phosphatase that decreases LPS activity and inhibits the expression of the NF-kB/IkB pathway. Turmerones enhance the bioavailability and bioactivity of curcumin. Turmerin inhibits oxidative DNA damage, formation of lipid peroxides, and arachidonic acid release. Curcumol inhibits oxidative stress and targets key signaling pathways MAPK/ERK, PI3K/Akt and NF-kB. Cyclocurcumin exhibits synergistic bioactivity with curcumin and inhibits the release of TNF-alpha. Curdione inhibits the production of prostaglandin E2 (PGE2) and COX-2 expression. B-elemene downregulates pro-inflammatory cytokines TNF-alpha, IFN, TGF-beta, IL-6 and IL-10. This matrix of bioactive compounds supports a healthy GI tract, enhances detoxification, creates a healthy microbiome, and helps maintain normal inflammatory balance.

Turmeric and its phytonutrients, like curcumin, have been shown to support lowering of lipid peroxidation by maintaining the activity of antioxidant enzymes — such as superoxide dismutase, catalase and glutathione peroxidase — at higher levels. In animal studies, curcumin was reported to decrease the release of reactive oxygen species from macrophages and inhibit histamine release from mast cells. The chemical structure of the curcumin molecule allows it to have a significant effect on oxidative stress and immune-mediated reactions. However, several findings indicate that antioxidant and protective effects are synergistically enhanced when other turmeric components are included.

A complete turmeric matrix was tested for its impact on immune cells and showed a three-fold increase in phagocytic ability. A meta-analysis of eight randomized, controlled trials indicated that doses of 1,000 mg of curcumin per day were effective in balancing overactive immune challenges. In a randomized, double-blind, placebo-controlled clinical trial published in the Journal of Medicinal Food, 36 patients with immune challenges were given 250 mg or 500 mg of a complete turmeric product twice daily. The results indicated that a complete turmeric formulation improved objective measurements and maintained normal inflammatory balance.

All sources of orally consumed nutrients must pass through the gut before moving along to the rest of the body. The gut microbiome is now considered influential in every aspect of human metabolism, making it an important mediator of phytonutrients. Turmeric and its phytonutrients, like curcumin, have been shown to support expression of protective proteins such as Nrf2. They also support normal balance of the expression of various inflammatory agents in the gut, such as NFkB, COX enzyme(s), and matrix metalloproteinase-9, and boost NK cell activity. The mechanism of action of curcumin allows it to indirectly bind to toll-like receptor 4 (TLR4), supporting a balance in the innate immune response to lipopolysaccharides (LPS). Furthermore, turmeric can help attenuate LPS-induced cytokine release and tight junction protein disruption, promoting overall gut mucosal health and equilibrium in inflammatory responses.

Bioavailability is defined as the delivery of a biologically active compound to a target tissue — it is not simply the absorption of higher amounts of the nutrient into the blood. There has been continuous debate on the bioavailability of curcumin, and most clinical research of turmeric-derived compounds is focused on curcuminoid activity. Curcuminoids undergo extensive metabolism during and after ingestion, which is one key reason curcumin is often encouraged to be consumed with an adjuvant or "bioavailability enhancer." However, these enhanced versions show no significant impact in human clinical studies — studies showing increased absorption have not demonstrated increased positive clinical outcomes. Based on this, it is important to shift focus to bioefficacy, or the effectiveness of a material in a biological environment, over bioavailability. Components of the whole turmeric root have proven that the therapeutic effect of turmeric extends beyond curcuminoids alone.